Posted: Fri 10th Jun 2016

Medical Research Council (MRC) Has Awarded A Team Of UK Scientists /
This article is old - Published: Friday, Jun 10th, 2016

The Medical Research Council (MRC) has awarded a team of UK scientists a £1.75m grant to study how a specific genetic variant known to increase risk for dementia affects the brain. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

The researchers – from Cardiff, Bristol and Oxford Universities – are combining their expertise to study how patterns of brain structure and activity in early adulthood might be linked to increased risk of dementia in later life. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Dementia costs the UK economy an estimated £24 billion annually. If research can identify methods to delay the start of dementia by five years, this cost could be halved. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Working with Bristol University’s unique birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC), they will ask whether healthy adults with APOE-e4, a genetic variant associated with a greater risk of Alzheimer’s disease, show altered patterns of brain activity and connectivity in key brain circuits involved in spatial navigation and memory. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Using powerful new scanners recently installed at Cardiff University’s Brain Research Imaging Centre (CUBRIC) the researchers are able to assess brain structure and function in unprecedented levels of detail. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Previous research by the team has demonstrated that carriers of APOE-e4 show specific differences in brain activity (compared to non-carriers) when they have to tell apart or remember different views of a scene or spatial environment. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

These changes are seen in the same brain regions affected early on in Alzheimer’s disease. By applying these sensitive cognitive tests in ALSPAC participants, the researchers will be able to ask how profiles of physical and mental activity, from birth to young adulthood, affects APOE-e4’s influence on brain activity during these tasks. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Principal Investigator of the study, Professor Kim Graham, School of Psychology, said: “Understanding how risk factors for dementia lead to later life memory loss is critical to developing new therapies and preventative approaches for dementia. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

“By collaborating with Bristol and Oxford Universities, and using new state-of-the-art neuroimaging in a unique birth cohort, we hope to understand the ways in which brain activity and structure is influenced by APOE-e4. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

“This information will generate sensitive cognitive tests and markers of brain function able to identify individuals at increased risk for dementia many years prior to the onset of memory difficulties.” ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Co-Principal Investigator, Clare Mackay, from Oxford University, added: “We increasingly recognize that to tackle complex diseases such as dementia we must pool expertise and resources. As partners in the MRC’s Dementia’s Platform UK the Cardiff-Oxford-Bristol team now have an opportunity to develop a clearer understanding of why some people are at greater risk of developing dementia.” ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Executive Director of ALSPAC, Lynn Molloy, commented: “ALSPAC is delighted to be collaborating with Professor Graham and colleagues on this exciting new study. ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

“This remarkable, intensely studied group of study participants are now entering their mid-twenties and this study will provide new insights into how brain changes at this age might be inked to increased dementia in later life.” ‌​‌​‌​​​‍‌​‌​​‌‌‌‍‌​‌‌​​‌​‍‌​‌‌‌​‌‌‍‌​‌‌‌‌​​

Spotted something? Got a story? Email News@News.Wales

More from Cardiff University

Family Court Transparency

Cardiff University

New Pro Vice-Chancellor

Cardiff University

Pregnant Women And New Mothers Feel Watched And Judged

Cardiff University

FRS And Nobel Prize Winner Is To Step Down As Chancellor Of Cardiff University

Cardiff University

Reflecting On A ‘Momentous Year’

Cardiff University

Type 2 Diabetes On The Rise

Cardiff University

Latest from News.Wales

Meeting new Welsh housing quality standards will be “incredibly challenging” for Cardiff Council, says official

Cardiff Council

Consultants Sought to Help Map New National Park in North-East Wales

Flintshire Council

Calls for Better Maintenance of Cardiff Cycle Paths as Puddles and “Minor Lake” Pose Safety Risks

Cardiff Council

Haverfordwest Town Museum Relocates to Town Centre During Castle Building Works

Pembrokeshire Council

New special school in Swansea to benefit young people with additional needs

Swansea Council

Proposed Name for Gwent’s Newest Welsh-Medium School to be Considered by Councillors

Monmouthshire Council